How can science embrace the unique expertise and lived experience of the nation’s diverse communities? When the public becomes more involved in science, what will they want? And how will that challenge scientists—and science itself—as it becomes a tool available to every American? In this issue we explore the potential of science that “makes space for everyone” by taking a close look at what scientists, communities, and policymakers alike are learning about how communities and scientists can work together to create new types of knowledge.